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Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 148-160 doi: 10.15302/J-FASE-2019305

Abstract:

Selecting beneficial DNA variants is the main goal of animal breeding. However, this process is inherently inefficient because each animal only carries a fraction of all desirable variants. Genome editing technology with its ability to directly introduce beneficial sequence variants offers new opportunities to modernize animal breeding by overcoming this biological limitation and accelerating genetic gains. To realize rapid genetic gain, precise edits need to be introduced into genomically-selected embryos, which minimizes the genetic lag. However, embryo-mediated precision editing by homology-directed repair (HDR) mechanisms is currently an inefficient process that often produces mosaic embryos and greatly limits the numbers of available edited embryos. This review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated breeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos. It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with elite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism, enable multiplex editing and multiply rare elite genotypes. Such a breeding strategy would enable a more targeted, accelerated approach for livestock improvement that allows stacking of beneficial variants, even including novel traits from outside the breeding population, in the most recent elite genetic background, essentially within a single generation.

Keywords： animal breeding     cattle     cloning     CRISPR/Cas9     cytoplasmic injection     embryo     genome editing     germline chimaeras    

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Three-dimensional numerical simulation for plastic injection-compression molding

Yun ZHANG, Wenjie YU, Junjie LIANG, Jianlin LANG, Dequn LI

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 1,   Pages 74-84 doi: 10.1007/s11465-018-0490-1

Abstract:

Compared with conventional injection molding, injection-compression molding can mold optical partsIn this study, a 3D simulation method was developed for injection-compression molding.in the cavity were investigated by using the proposed simulation method and compared with those of injectionpressures at different points along the flow path is complicated rather than monotonically decreased in injection

Keywords： injection-compression molding     simulation     injection molding     melt flow     cavity pressure    

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Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 311-319 doi: 10.1007/s11684-016-0460-0

Abstract:

We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tailextracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmicintegrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic

Keywords： integrin β3     signal transduction     trans-dominant inhibition model    

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density measurement for plastic injection molding via ultrasonic technology

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0714-2

Abstract: Density variation during the injection molding process directly reflects the state of plastic melt andExperiments with different process conditions are conducted, including different melt temperature, injectioni> measurement, non-destructive, high accuracy, low cost, and is of great application value for the injection

Keywords： ultrasonic measurement     melt density     in-situ measurement     injection molding    

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Economic Development Models of Gas Condensate Reservoir

Liu Tingyuan

Strategic Study of CAE 2001, Volume 3, Issue 3,   Pages 85-91

Abstract: condensate reservoirs, including reinjection with 75% dry gas recycling, dumpflooding of gas, nitrogen injection, water injection, water and gas alternating injection, C〇2 injection, etc.

Keywords： gas condensate reservoir     development model     gas injection     nitrogen injection     water injection     CO 2 injection     economic    

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Trend prediction technology of condition maintenance for large water injection units

Xiaoli XU, Sanpeng DENG

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 2,   Pages 171-175 doi: 10.1007/s11465-009-0091-0

Abstract: Large-sized water injection units are key equipment in oilfields.maintenance costs, trend prediction technology is studied to achieve condition-based maintenance for water injectionproposed trend prediction technology can reflect the operating condition trend change of the water injection

Keywords： water injection units     condition-based maintenance     trend prediction    

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Intelligent methods for the process parameter determination of plastic injection molding

Huang GAO, Yun ZHANG, Xundao ZHOU, Dequn LI

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 1,   Pages 85-95 doi: 10.1007/s11465-018-0491-0

Abstract:

Injection molding is one of the most widely used material processing methods in producing plasticstudies and developments of the intelligent methods applied in the process parameter determination of injection

Keywords： injection molding     intelligent methods     process parameters     optimization    

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methodology for regulating fuel stratification and improving fuel economy of GCI mode via double main-injection

Frontiers in Energy 2023, Volume 17, Issue 5,   Pages 678-691 doi: 10.1007/s11708-022-0859-z

Abstract: regulating concentration stratification and promoting fuel-gas mixing by utilizing the double main-injectioninjected gasoline with an octane number of 82.7 to investigate the energy ratio between the two main-injectionHigh-load experiments were conducted using the DMI strategy and compared with the single main-injectionAt a 10 bar indicated mean effective pressure, increasing the main-injection-2 ratio (Rm-2) shortens the injection duration and increases the mean mixing time.

Keywords： gasoline compression ignition     injection strategy     fuel stratification     high efficiency     high load    

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CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Frontiers in Energy 2023, Volume 17, Issue 3,   Pages 428-445 doi: 10.1007/s11708-023-0865-9

Abstract: For the core flooding tests, pure gas injection showed that the breakthrough time of CO2 was of CO2 gas injectionFor CO2/N2 mixed gas injection, with the increase of CO2 concentration of the pure CO2 gas injection

Keywords： shale gas     gas injection     competitive adsorption     enhanced shale gas recovery     CO2 geological    

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Experimental study of stratified lean burn characteristics on a dual injection gasoline engine

Chun XIA, Tingyu ZHAO, Junhua FANG, Lei ZHU, Zhen HUANG

Frontiers in Energy 2022, Volume 16, Issue 6,   Pages 900-915 doi: 10.1007/s11708-021-0812-6

Abstract: In this study, dual injection stratified combustion mode is used to accelerate the burning rate of leanThe effects of engine control parameters such as the excess air coefficient (Lambda), direct injectionand DI timing on combustion, fuel consumption, gaseous emissions, and particulate emissions of a dual injectionThere exists a spark window for dual injection stratified lean burn mode, in which the spark timing hasThe dual injection stratified lean burn has a wide range of applications which can effectively reduce

Keywords： dual injection     stratified lean burn     gasoline engine     particulate matter emission     combustion analysis    

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Treatment of gingival hyperplasia induced by cyclosporine A

MA Jingzhi, LI Ming, CAO Yingguang

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 290-294 doi: 10.1007/s11684-008-0055-5

Abstract: Under transmission electron microscopy, fibroblasts in the hyperplastic gingival tissues were enlarged, cytoplasmic

Keywords： post-transplantation     Gingival     cytoplasmic     CsA-induced     further    

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Microcellular injection molding process for producing lightweight thermoplastic polyurethane with customizable

Thomas ELLINGHAM, Hrishikesh KHARBAS, Mihai MANITIU, Guenter SCHOLZ, Lih-Sheng TURNG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 1,   Pages 96-106 doi: 10.1007/s11465-018-0498-6

Abstract:

A three-stage molding process involving microcellular injection molding with core retraction and anfoams of varying local densities, microstructures, and mechanical properties in the same microcellular injection

Keywords： thermoplastic polyurethane     microcellular injection molding     cavity expansion     compressive strength     hysteresis    

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Pressure in Gas-assisted Injection Molding

Ou Changjin

Strategic Study of CAE 2007, Volume 9, Issue 5,   Pages 27-32

Abstract: nbsp;an effective control method and strategy based on fuzzy neural network has been developed for gas injectionpressure accurate control in gas-assisted injection.

Keywords： gas-assisted injection molding     fuzzy neural network     gas-injection pressure control    

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Combustion characteristics of a direct-injection diesel engine fueled with Fischer-Tropsch diesel

HUANG Yongcheng, ZHOU Longbao, PAN Keyu

Frontiers in Energy 2007, Volume 1, Issue 2,   Pages 239-244 doi: 10.1007/s11708-007-0033-7

Abstract: pressures and injector needle lifts, the combustion characteristics of an unmodified single-cylinder direct-injectionThe results show that F-T diesel fuel exhibits a slightly longer injection delay and injection duration
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Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 267-276 doi: 10.1007/s11684-017-0586-8

Abstract: Shenkang injection (SKI) is a classic prescription composed of , rhubarb, , and .

Keywords： Shenkang injection     senescence     renal tubular epithelial cells     diabetic nephropathy    

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Title Author Date Type Operation

Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Journal Article

Three-dimensional numerical simulation for plastic injection-compression molding

Yun ZHANG, Wenjie YU, Junjie LIANG, Jianlin LANG, Dequn LI

Journal Article

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition

Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi

Journal Article

density measurement for plastic injection molding via ultrasonic technology

Journal Article

Economic Development Models of Gas Condensate Reservoir

Liu Tingyuan

Journal Article

Trend prediction technology of condition maintenance for large water injection units

Xiaoli XU, Sanpeng DENG

Journal Article

Intelligent methods for the process parameter determination of plastic injection molding

Huang GAO, Yun ZHANG, Xundao ZHOU, Dequn LI

Journal Article

methodology for regulating fuel stratification and improving fuel economy of GCI mode via double main-injection

Journal Article

CO, N, and CO/N mixed gas injection for enhanced shale gas recovery and CO geological storage

Journal Article

Experimental study of stratified lean burn characteristics on a dual injection gasoline engine

Chun XIA, Tingyu ZHAO, Junhua FANG, Lei ZHU, Zhen HUANG

Journal Article

Treatment of gingival hyperplasia induced by cyclosporine A

MA Jingzhi, LI Ming, CAO Yingguang

Journal Article

Microcellular injection molding process for producing lightweight thermoplastic polyurethane with customizable

Thomas ELLINGHAM, Hrishikesh KHARBAS, Mihai MANITIU, Guenter SCHOLZ, Lih-Sheng TURNG

Journal Article

Pressure in Gas-assisted Injection Molding

Ou Changjin

Journal Article

Combustion characteristics of a direct-injection diesel engine fueled with Fischer-Tropsch diesel

HUANG Yongcheng, ZHOU Longbao, PAN Keyu

Journal Article

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Journal Article